INTRO
2024
THE
LABS
Aging is the ultimate disease
and it is treatable
THE KEY TO
LONGEVITY
longevity
/lɒnˈdʒɛvɪti/
long duration of life, length of life
Humanity’s greatest
threat is Aging
With age, we lose the capacity to replace dead cells or repair damaged DNA
94%
of people pass away due to age related illnesses
50bn
cells die in the body everyday
80%
decline in stem cell diversity
after the age of 70
240+
DNA breakages per day
Hallmarks of Aging
DNA Level
Cell
Level
Organ Level
Genomic Instability
Epigenetic Alterations
Telomere Attrition
Loss of Proteostasis
Cancer / Alzheimer’s /
Parkinson’s
Deregulated Nutrient Sensing
Mitochondrial Dysfunction
Cellular Senescence
Altered Intercellular Communication
Stem Cell Exhaustion
Chronic Inflammation
Gut Dysbiosis
Extracellular Matrix Dysfunction
Sarcopenia / Arthritis / Diabetes / Osteoporosis /
Atherosclerosis
COPD /Heart Disease /
Chronic Kidney Disease /
Liver Cirrhosis / Stroke
Stem cells are the body’s
solution to combat Aging
The progress that
will change our lives
21%
$600bn
longevity market’s annual growth rate
expected longevity market value by 2025
$26bn
3,700+
expected stem cell market value by 2026
active cell and gene based clinical trials taking place worldwide
A multi-billion dollar industry
is currently growing in labs
The KEY’s vision was realized
by the pioneers at Stemaid
12,000+ patients treated
Unmatched variety of medical conditions treated
Crucial treatment protocols based on unique track record
20+ years of research
10+ years of clinic operations
$25m in investment
60,000+ procedures performed
2004
Formation of stem cell lab
2007
Stemaid’s global expansion
is The KEY
2010
2022
2024
Clinical trials
begin
Commencement of stem cell distribution
Commencement production of
skin-cell derived pluripotent stem-cells
Global
expansion
PLURIPOTENT
STEM CELLS
Can differentiate into nearly any
cell type in the body
There are two types
of stem cells
Traditional Product Portfolios:
MULTIPOTENT
Can differentiate into a limited range of cell types within a specific tissue or organ
The KEY Product Portfolio:
PLURIPOTENT
Remarkable ability to transform into almost any cell type within the human body,
offering unparalleled potential for regenerative medicine and therapeutic applications
Why use Pluripotent stem cells?
Safe and effective
Anti-tumor ‘cancer vaccine’ effect not found in adult or umbilical-cord stem cells
Lengthen the telomeres of our DNA
Contain the Nanog gene, known for its anti-aging benefits
Express Micro RNAs that aid in reversing keloids and scarring
More potent than adult or umbilical-cord stem cells in helping the body to heal
Yamanaka factors
Immune modulator
Regenerates damaged tissues
Pluripotent stem cells without ethical concerns
Traditionally, pluripotent stem cells were derived from donated blastocyts, raising ethical and practical issues.
We developed a novel method to reprogram adult skin cells into pluripotent stem cells, without requiring any embryonic material. This means that we can produce stem cell lines that are customized for each patient, using their own skin cells. These are called autologous pluripotent stem cells
No embryos involved
Yamanaka & Nanog factors
Advanced reprogramming
How does it work
Donor Tissue Selection
Sample Collection and Culturing
Somatic Cell Nuclear Transfer (SCNT)
Blastocyst Formation
Pluripotent Stem Cells & Exosomes
A young and healthy adult donor is carefully selected. Donor consent is obtained, and genetic, viral screening, and HLA typing are performed pre- and post-collection. The process is overseen by an institutional review board and a specialized screening panel
A small skin sample is collected from the donor, from which dermal fibroblasts are cultured and prepared for the SCNT process
The nucleus of the cultured dermal fibroblast is transferred into an enucleated egg (an egg cell with its nucleus removed). The egg’s cytoplasm reprograms the somatic nucleus, transforming it into a zygote nucleus capable of initiating embryonic development
The reprogrammed egg is allowed to develop into a blastocyst, an early-stage embryo. From the blastocyst's inner cell mass, embryonic stem cells are cultured, and exosomes are extracted
The cultured stem cells and exosomes are pluripotent, meaning they have the potential to differentiate into over 220 tissue types, offering versatile therapeutic applications
Why our method is superior
Our Method
iPSCs
Utilizes Yamanaka factors in a controlled manner, ensuring natural DNA stability with minimal risk of unpredictable changes
Natural Stability
Actively targets and removes potential tumor cells, reducing the risk of cancer
Tumor Prevention
Involve elevated levels of Yamanaka factors, which, when activated in the nucleus, can lead to significant epigenetic changes, increasing the risk of DNA instability
Risk of Instability
Does not naturally remove tumor cells, potentially increasing the risk of oncogenesis
Tumor Risk
Stem cell treatment is truly
a next-level health innovation
that can reverse the wear
and tear we put on our bodies
and prevent debilitating diseases
and injury from escalating further
tony robbins
PLURISOMES
Plurisomes are Pluripotent Exosomes. Exosomes are secretory vesicles released by stem cells. These vesicles play a pivotal role in intercellular communication by transferring their cargo of proteins, lipids, nucleic acids, and other bio-active molecules to recipient cells.
These incredible cells release reparative secretome in response to tissue or medium conditions.
In a clean laboratory setting, Plurisomes are cultured in an ideal in-vitro medium that is completely free from the inflammatory and toxic milieu present in vivo.
Highly Specific Messaging Content
Comprehensive Tissue Repair
What are the benefits
of Plurisomes ?
Multi-Tissue Biodistribution
Plurisomes contain a wide range of growth factors, peptides, messenger RNA, and micro-RNA that are vital for multi-tissue renewal and repair.
These specific messaging contents play a crucial role in signaling restoration and rejuvenation at any juncture of tissue biology.
Pluripotent stem cells and their secreted exosomes have the remarkable ability to repair and restore all 220+ tissue types in the human body.
Their reach is truly comprehensive, making them a powerful tool for whole organism rejuvenation.
Clinical evidence has shown that Plurisomes have a multi-tissue comprehensive bio-distribution.
This means that upon application, the therapeutic message of Plurisomes travels to all tissues of the body, ensuring that no area is left untouched.
Exosomes
Plurisomes
vs
Derived from various cell types
Derived exclusively from Pluripotent stem cells
Source
High, due to pluripotent origin allowing differentiation into any cell type
Limited by the source cell type
Regenerative Potential
Enriched with Pluripotency factors, enhancing regenerative capacity
Varies widely; may not include pluripotent-specific factors
Protein and RNA Content
Broad applicability across multiple tissues and conditions due to Pluripotent properties
Therapeutic Application Range
Typically targeted for specific tissues or conditions
Superior, with enhanced regenerative capabilities and potential to address complex conditions
Moderate, dependent on source
Efficacy in Regeneration
Pluripotent Factors Includes KEY reprogramming factors like Klf4, Oct4, Sox2, cMyc
Molecular Diversity Contains over 60,000 different molecules, including essential microRNAs and mRNAs
Comprehensive Effects Effective in tissue regeneration, immune modulation, and neuroprotection
Exosome therapy is the next big thing in skincare - it's all about rejuvenation and getting that youthful glow back
KIM KARDASHIAN
Pluripotent products address
all Hallmarks of Aging
Deregulated Nutrient Sensing
Restore the balance of nutrient-sensing pathways, such as insulin and IGF-1 signaling
Genomic Instability
Plurisomes express DNA repair factors
Telomere Attrition
Evidence of Telomereelongation
after treatment
Balance immune response and has anti-inflammatory effect
Chronic Inflamation
Epigenetic Alteration
Plurisomes rejuvenate senescent stem cells
Pluripotent genes specialise in edigenetic reprograming
Stem Cell Exhaustion
Mirnas from Plurisomes contribute to restore communication
Altered Intercellular Communication
Disabled Macroautophagy
Autophagic machinery activated
Pluripotent stem cells share their young and healthy mitochondria
Repair the damage done by the presence of harmful bacteria
Mitochondrial Dysfunction
Gut Dysbiosis
Plurisomes express senolytic, known to rejuvenate senescent stem cells
Replenishes damaged or misfolded proteins and restoring proper protein function
Cellular Senescence
Loss of Proteostasis
We cannot predict the future, but we can create it by advancing stem cell research and regenerative medicine
Dr. Shinya Yamanaka
Product Range
Pluripotent Stem Cells
PEptides
Generic & Autologous
via IV
Epithalon, Thymosin Alpha, Cerebrolysin, BPC-157, Chelation, B-17, GHK-Cu
PLURISOMES
Targeted Injections or
via IV
GENE enhancement
Follistatin, Klotho
Product Pipeline
Skin Care Products
Look Better
Stay Active
KEY Deliverables
Age Healthier
Skin and hair have the potential for rejuvenation by leveraging the power of our own cells to fight the effects of aging.
Enhance vitality and maintain physical performance by utilizing cutting-edge treatments that support muscle strength and joint health.
The effects of aging accelerate as we get old, leading to disease and frailty. Regenerative cell treatments could help replenish what we lose with age and bring us back to a healthier state.
Join a global network of industry pioneers backed by world
renowned science
Supply Chain
1
2
KEY Clinics
KEY Holding LLC
are the treatment centers operated by franchisees under the sub brand „KEY“
holds the know-how and research pool in advanced stem cell therapeutics and makes them accessible to clinic & upscale wellness operators around the globe
KEY Labs
KEY Cells
R&D and production of The KEY Cells product line. Fully equipped, GMP compliant laboratories
are the pluripotent products that are cultivated in the laboratories and shipped to the franchisees
KEY Terms
STRUCTURE
Straightforward fees: $500k initiation fee for exclusivity, know-how transfer and marketing material
Exclusivity will last for 3 years and will be extended by 3 years if the clinic has met its KPIs
Exclusivity period incepts on the day of treating the first patients
Minimum order quantity of 900 procedures per annum
20% franchise fee on gross revenue
Franchisor
Production and daily delivery of finished products to Franchisees clinic
Laboratory set-up and licensing (c GMP)
Regulatory approval of products/therapies
Ongoing consultation on treatment protocols
Training and education of Franchisees personnel
Comprehensive branding and marketing support
Client referrals
Franchisee
Has or will acquire licence to operate a medical clinic/practice
Has or will recruit qualified practitioners (MD, Nurse)
Administration of therapies based on strict treatment protocols
Marketing & customer acquisition
Exclusivity, referrals, brand usage to be agreed
THE
LABS
Franchisee Requirements
Treatment Facility
1 Medical Doctor onsite for consultation and targeted injections
1 qualified person for facial treatments (micro needling / facial injections)
1-3 Nurses for IV administration
Cool storage for IV bags and Plurisomes vials
40-50sqm treatment area for IV
Treatment room for facials
Laboratory
Franchisor Infrastucture
Clean Room ISO 7
Incubators and/or Bioreactors
Microscopes
Equipment for analysis of the stem cells and plurisome composition
Cryostorage equipment
The KEY is not about feeling and looking younger - it is about
being younger
INTRO
2024
THE
LABS
THANK YOU
For further information please contact us at
info@thekey-labs.com
DISCLAIMER
This company presentation (“Presentation”) has been prepared by KEY Holding LLC and its affiliates (together, the “KEY”) solely for information purposes and should not be considered an advertisement or offer to sell or solicitation to buy any securities in any jurisdiction. This Presentation does not constitute legal, business, tax or professional advice. The KEY provides this Presentation on a strictly confidential basis solely to the recipient to whom it was delivered by the KEY. The acceptance of this Presentation constitutes an agreement on the part of the recipient hereof and the recipient’s representatives to maintain the confidentiality of the information contained herein. No part of this Presentation may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, without the prior written permission of the KEY. If you received this Presentation without the KEY’s express consent, disregard the entirety of this Presentation, and please destroy all record of it and advise the KEY immediately of its unauthorized distribution. The delivery of this Presentation does not include any representation that there has been no change in the affairs of the KEY since the date this Presentation was prepared.